PPARGC1A and Parkinson disease: AMPK/SIRT-1/PGC-1α-mediated autophagy (Lee et al., 2023; Elesawy et al., 2024), mitochondrial biogenesis (Liu et al., 2022; Jhuo et al., 2024) PGC-1α/Nrf mediated oxidative stress (Guo et al., 2023) were all classical pathway in PD.