Table 5 shows that only three cytokines aside from RANK-RANKL-OPG and TGF-β are explicted modeled: IL-6, MCSF, and IGF. One benefit of including other cytokines in bone models is the potential to explore their importance under various remodeling conditions, yet many models with cytokines lack this analysis. For example, IGF is included in Garzón-Alvarado (2012) to simulate osteosclerosis because tumors are known to increase IGF levels and thus increase osteoblast activity. This evidence concerns the gene IGF1 and osteosclerosis.