Through the interaction between its flagellin and leucine-rich repeat containing 19 (LRRC19), Desulfovibrio vulgaris activates the TNF receptor-associated factor 6 (TRAF6)/transforming growth factor-β-activated kinase 1 (TAK1) signaling pathway, thereby promoting epithelial-mesenchymal transition and driving the progression of colorectal cancer (Dong et al., 2025). The gene discussed is LRRC19; the disease is colorectal cancer.