As a model of AD, we used the 5xFAD mouse line with the C57BL6J genetic background, which carries five familial Alzheimer’s disease (FAD) mutations in APP and PS1 genes, resulting in overexpression of Aβ42 and rapid accumulation of Aβ plaques in the brain (Holly et al., 2006). This evidence concerns the gene PSEN1 and familial Alzheimer disease.