Targeting CNS cells expressing α7-nAChRs has revealed their crucial role in neurodevelopment (Wu et al., 2015), neuroprotection (Gaidhani and Uteshev, 2018), neurodegenerative diseases (Callahan et al., 2013; Gowayed et al., 2022), and psychiatric disorders (McLean et al., 2012; Targowska-Duda et al., 2021). The gene discussed is CHRNA7; the disease is neurodegenerative disease.