In patients with memory-impairing conditions, such as medial temporal lobe epilepsy and Alzheimer’s disease, cortical atrophy and tau protein deposition were also evident in the connected limbic regions other than MTL (Franzmeier et al., 2019; Tavakol et al., 2019; Tetreault et al., 2020; Park et al., 2022). The gene discussed is MAPT; the disease is Alzheimer disease.