TARDBP and proteostasis deficiencies: Recent advancements have explored the use of TDP-43 as a biomarker for TDP-43 proteinopathies in various biofluids, such as serum, cerebrospinal fluid, and tear film (Cordts et al., 2023; Chalkias et al., 2021; Majumder et al., 2018; Giampietri et al., 2022).