TARDBP and Neurodevelopmental delay: Due to overlapping phenotypes, symptom heterogeneity, the topographic distribution of TDP-43 neuropathology, and the often insidious nature of NDD development, these diseases are usually definitively confirmed via neuropathological examination of brain lesions upon autopsy, resulting in delays in diagnosis (Baldacci et al., 2020; Cordts et al., 2023).