TARDBP and proteostasis deficiencies: FTD is the second most common presenile or early-onset dementia after AD and has many variants, including behavioral, language, and/or motor dysfunction (Arseni et al., 2022; Dijkstra et al., 2023), with one of the three main pathological subtypes being TDP-43 proteinopathy (Baldacci et al., 2020).