For the scaffold system, a gelatin sponge scaffold modified with neurotrophin-3 (NT-3)/SF can achieve a controlled-artificial release system with significant inflammatory inhibitory activity in the rat spinal cord injury (SCI) model, as shown by a significant reduction in the number of IBA-1 positive and CD68 positive macrophages/microglia (Li et al., 2018; Li G. et al., 2016). Here, NTF3 is linked to spinal cord injury.