NFE2L2 and chronic obstructive pulmonary disease: Zhou and colleagues proposed that luteolin alleviates oxidative stress induced by CS in COPD by modulating the transient receptor potential vanilloid type 1 (TRPV1) and cytochrome P450 family 2 subfamily A member 13 (CYP2A13)/nuclear factor erythroid 2-related factor 2 (NRF2) signaling pathways.