Additionally, Chen et al., by knocking down STAT3, demonstrated that luteolin decreases phosphorylation in the JAK/STAT pathway while elevating SOCS3 levels, thereby eliminating the suppressive effect of LPS-induced ENaC expression, indicating that luteolin can alleviate ALI/ARDS by enhancing transepithelial sodium transport through the JAK/STAT pathway (Chen et al., 2023). This evidence concerns the gene SOAT1 and acute respiratory distress syndrome.