Numerous studies have indicated that the abnormal activation of the PI3K/AKT pathway in RA is closely associated with multiple pathological processes, including the promotion of persistent abnormal proliferation of synovial cells, accelerated synovial angiogenesis, cartilage destruction, and the enhancement of osteoclastogenesis leading to bone erosion (Ding et al., 2023; Jiang et al., 2024). Here, AKT1 is linked to rheumatoid arthritis.