It normalizes blood vessels, fine-tunes the immune contexture of the tumor, and fosters the penetration of immune cells into the tumor mass, lenvatinib exhibits inhibitory effects on IFN-γ signal transduction in tumor cells through targeted modulation of FGFR, thereby amplifying the immunological effects of PD-1 inhibitors against HCC (31, 32). Here, IFNG is linked to hepatocellular carcinoma.