Regarding AEs classified as grade 3 or above, the HAIC-L-P group exhibited elevated risk ratios for Vomiting (RR = 3.98, 95% CI: 1.51–10.50, P = 0.005), Elevated AST (RR = 2.67, 95% CI: 1.66–4.28, P = 0.0001), Elevated ALT (RR = 1.85, 95% CI: 1.20–2.84, P = 0.005), Thrombocytopenia (RR = 3.27, 95% CI: 1.81–5.91, P = 0.0001), Neutropenia (RR = 6.69, 95% CI: 2.08–21.52, P = 0.001), and Hyperbilirubinemia (RR = 2.78, 95% CI: 1.47–5.23, P = 0.001) compared to the L-P group, with these differences attaining statistical significance. This evidence concerns the gene GPT and Decreased total neutrophil count.