In terms of frequency of all grades AEs, the HAIC-L-P group exhibited a greater likelihood of experiencing Abdominal pain(RR =1.97, 95%CI: 1.27-3.08, P=0.003), Decreased appetite(RR =1.47, 95%CI: 1.21-1.78, P=0.0001), Vomiting(RR =2.60, 95%CI: 1.46-4.60, P=0.001), Elevated AST(RR =2.42, 95%CI: 1.41-4.17, P=0.001), Elevated ALT(RR =2.00, 95%CI: 1.34-2.98, P=0.0007), Thrombocytopenia(RR =2.00, 95%CI: 1.34-2.98, P=0.0007), Anaemia(RR =1.69, 95%CI: 1.23-2.32, P=0.001), Neutropenia(RR =2.80, 95%CI: 1.27-6.18, P=0.01), Hyperbilirubinacemia(RR =1.54, 95%CI: 1.03-2.29, P=0.03) than the L-P group. The gene discussed is GPT; the disease is Decreased total neutrophil count.