Additionally, ITGA4 expression varied among multiple Immunosuppressive datasets, showing high levels in METABRIC, TCGA Melanoma, ICB_Nathanson2017_CTLA4, and ICB_VanAllen2015_CTLA4 cohorts, but low in GSE12417_GPL570, Patel2017 1, and Shifrut 2018 pilot Average cohorts (Figure 6E). This evidence concerns the gene CTLA4 and melanoma.