Notably, our proteomics data indicate ATR is not the only protein involved in DDR and genomic stability regulated by AEP, suggesting AEP plays a broader role in the regulation of these key biological processes, that will require further investigation.On the other hand, we show that AEP reduces PPP1R10 levels, leading to sustained Chek1 and P53 phosphorylation, thus promoting the activation of the G2/M checkpoint and facilitating DNA damage repair in response to genotoxic insults in BC. This evidence concerns the gene ATR and breast cancer.