Remarkably, similar findings were obtained in U2OS cells (Supplementary Figs. 5F and G), in which we previously showed that AEP-deficiency also resulted in cell death (Supplementary Fig. 1) and increased ATR levels (Supplementary Fig. 2), validating our hypothesis and the novel role of AEP as a regulator of ATR levels and as therapeutic target to sensitize cancer cells to genotoxic insults. This evidence concerns the gene LGMN and cancer.