Notably, a significant increase in both the percentage of micronuclei-containing cells (Fig. 1I) and an increase in the number of polyploid cells (Fig. 1H and J and Supplementary Fig. 1D) in AEP KD MDA-MB-231 cells were observed, suggesting a potential role for AEP in suppressing genomic instability in BC cells. The gene discussed is LGMN; the disease is breast cancer.