CAV3 and diabetes mellitus: Additionally, our further study has found that knockdown of Cav-3 by siRNA increases the levels of superoxide anion (O2•−) in cardiomyocytes, a main oxidizing substance during I/R, and improving Cav-3 expression attenuates ROS production and postischemic injury in diabetes (Lei et al. 2019; Su et al. 2016).