CAV1 and liver disorder: Recent study shows that deficiency of Cav-1 promotes cholesterol accumulation and exacerbates ER stress in a murine model of metabolic dysfunction-associated steatotic liver disease, while supplementing CSD by intraperitoneally injection, a stable analog of the active domain of Cav-1, can alleviate ER stress and it-mediated pyroptosis (Xu et al. 2025).