It has been shown that mice with genetic ablation of Cav-3 exhibit impaired insulin signaling, abnormal glucose and lipid metabolism, adiposity, and insulin resistance with ligand-induced insulin receptor instability in skeletal muscle, which has similar features to type 2 diabetes (Capozza et al. 2005; Oshikawa et al. 2004). This evidence concerns the gene INS and type 2 diabetes mellitus.