We initially measured the mRNA expression levels of the HER family in ovarian tumor tissues, which include EGFR, HER2, HER3, and HER4, and found a significant negative correlation between the expression levels of HER3 and levels of CYLD (Fig. 5A), but not levels of other HER family members (Fig. S5A). This evidence concerns the gene ERBB3 and ovarian neoplasm.