In a supervised analysis using a manually curated set of genes known to be important in MM growth and survival (Supplementary Fig. S8), we identified increased expression of molecules involved in the Notch pathway, and greater expression of Vegf-a in MSC-lineage clusters 0, 2 and 4 and Igf1 in clusters 0, 1, and 4. Here, IGF1 is linked to Miyoshi myopathy.