Beside the hormonal clusters we described some substantial differences between NSGCT and seminoma: in both cohorts, the POMC gene, which regulates steroid biosynthesis, along with genes involved in metabolism (HSD17B1, HSD17B2, SRD5A1), and sex hormone transport (SHBG), showed significant upregulation in NSGCT compared to seminoma. The gene discussed is SHBG; the disease is seminoma.