In the TCGA cohort, seminoma was characterized by the highest expression of LHB (luteinizing hormone subunit beta) and SRD5A3. High mRNA levels of genes coding for pituitary gonadotropin subunits CGA and GNRH2 hallmarked mixed germ cell tumors and embryonal carcinomas. The gene discussed is SRD5A3; the disease is embryonal carcinoma.