The copy numbers of wtAd significantly increased at 24 h infection compared to 1 h infection in COX-2 negative BT474 and COX-2 positive KK47, 5637, and T24 cells (p < 0.01; Fig. 3a), whereas the copy numbers of ADX730 did not increase in any of the cell lines (Fig. 3b). The gene discussed is PTGS2; the disease is infection.