SENP6 and infection: We confirmed that CRISPRi-ART knockdown of RIIA or RIIB encoded by T4, MM02, EdH4, SUSP1 and N4 phages—spanning four distinct subfamilies and five genera—does not inhibit their infection of E. coli lacking Rex, suggesting that these genes are not broadly critical for efficient infection in the absence of Rex-encoding prophages (Fig. 4c,d and Supplementary Figs. 15–20).