Severn families of deubiquitinase enzymes have been identified to date; ubiquitin C-terminal hydrolases (UCHs), ubiquitin-specific proteases (USPs), ovarian tumour proteases (OTUs), JAB1/MPN/MOV34 metalloenzymes (JAMMs), the Machado-Josephin domain superfamily (MJD), the MINDY family, and the ZUFSP family members [23, 24]. This evidence concerns the gene ATXN3 and neoplasm.