PBRM1 and renal carcinoma: We further tested this using a panel of six renal cancer cell lines, in which three have loss of function mutations in PBRM1, and we found that PBRM1 deficient cells are considerably more sensitive to CCNB1 depletion than the PBRM1 proficient cell lines (Fig. 6i–k, and Supplementary Fig.12d, e), suggesting potential clinical implications.