While the use of a simplistic immunization approach in this study allows precise analysis of the T cell priming kinetics, the mechanism for disease-associated Th2 cell differentiation may need to be further examined in a more complex setting such as allergies and helminth infection, as such condition can potentially induce Il4ra even in naïve CD4+ T cells in an antigen-nonspecific manner94. This evidence concerns the gene IL4R and allergic disease.