The increased expression of GLUT2 can promote glucose uptake by tumor cells, enhance glycolysis, and promote tumor progression [41].In the present study, we uncovered that S100A2 enhances the transcriptional regulation of GLUT2 through its interaction with HNF1A, thereby boosting the ability of ccRCC cells to uptake glucose. This evidence concerns the gene S100A2 and nonpapillary renal cell carcinoma.