HNF1A and nonpapillary renal cell carcinoma: The increased expression of GLUT2 can promote glucose uptake by tumor cells, enhance glycolysis, and promote tumor progression [41].In the present study, we uncovered that S100A2 enhances the transcriptional regulation of GLUT2 through its interaction with HNF1A, thereby boosting the ability of ccRCC cells to uptake glucose.