RELB and metabolic syndrome: Other transcription factors stand out for their strong relation to inflammation, as this applies to RELB, a subunit of NF-kB that has been causally involved in metabolic syndrome and aging [49–51], MYC, which may drive inflammation in specific organ sites [52–54], as well as to STAT1, which operates in the interferon response pathway and hence contributes to aging [55, 56].