In addition, albeit hypersynchronization is characteristic feature of AD, some studies also report hyposynchronization (Cuesta et al., 2022; Ranasinghe et al., 2022; Schoonhoven et al., 2022), which might reflect either an advanced disease stage with a network breakdown (Pusil et al., 2019) possibly due to tau pathology (Canuet et al., 2015) or a different nonepileptiform AD phenotype (Maestú et al., 2021). This evidence concerns the gene MAPT and Alzheimer disease.