RIPK3 and cancer: Although RIPK3 is expressed in normal primary cells and tissues (Kasof et al., 2000, Koo et al., 2015, Newton et al., 2004, Sun et al., 1999, Yang et al., 2005, Yu et al., 1999), we observed a few years ago that RIPK3 expression is almost completely silenced (both at the mRNA and protein level) in a large majority of cancer cell lines from a large variety of different tissues, as well as many primary cancers.