Deficiency of RIPK3 in hepatocellular carcinoma is reported to increase M2 tumor-associated macrophages population associated with antitumor immunity, also leading to the conclusion that RIPK3 suppresses the protumorigenic effects (Wu et al., 2020) of the immune system in favor of the antitumor immunogenic responses. The gene discussed is RIPK3; the disease is hepatocellular carcinoma.