Furthermore, the functions of key regulatory factors, such as the Xc-/GSH/GPX4 axis, ACSL4/LPCAT3 pathway, and nuclear factor erythroid 2-related factor 2 (NRF2) in ferroptosis, as well as their potential dysregulation mechanisms related to cancer cell survival and drug resistance, have been thoroughly explored [60]. The gene discussed is LPCAT3; the disease is cancer.