XGB, RF, and LR significantly outperformed all the baseline comparison methods (ie, MDW [37], CRP [44], Sepsis Index [45], COMPOSER [25], as well as the SVM model developed in the study by Aguirre and Urrechaga [31]; Figures 1 and 2; Figure S1 in Multimedia Appendix 1) and did so across all possible decision thresholds. This evidence concerns the gene CRP and Sepsis.