For instance, frameshift variants in RFLNA have been linked to spondylocarpotarsal synostosis syndrome, a skeletal disorder characterized by short stature and carpal/tarsal synostosis.[34] The involvement of FOXO1 in embryonic development, bone growth and remodeling, and cartilage repair processes underscores its essential function in skeletal development.[35] Another signal was identified near the KIF2B gene, which belongs to the KIF family involved in nervous system development and early embryo. This evidence concerns the gene KIF2B and Spondylocarpotarsal synostosis.