Indeed, these studies have shown that TNF-α inhibition alleviates histopathological changes such as edema and ischemia (Guven et al. 2010), reduces the number of TUNEL-positive (apoptotic) cells (Genovese et al. 2006), and leads to improvements in locomotor deficits (Guven et al. 2010; Börcek et al. 2015) caused by trauma. The gene discussed is TNF; the disease is ischemia.