Two cases were heterozygous for both CHEK2 c.1100delC and RAD50 c.687delT: case 5 was reported to have a profuse amount of in situ component in addition to the invasive class T4 tumor, whereas case 6 (carrying also third, FANCM c.5101C > T, variant) was diagnosed simultaneously with three ductal/inflammatory tumors in one breast with skin involvement (T4). This evidence concerns the gene FANCM and neoplasm.