CXCL8 and intrahepatic cholangiocarcinoma: Then ICC cells were treated with IL-8 and found that IL-8 could upregulate the expression of ALDH1A1, while either SB225002 or NF-κB inhibitors (JSH-23) could inhibit ALDH1A1 expression upregulation by IL-8 (Figures 4B and C).