TE‐1 cells transfected with OE‐circCD44, OE‐circCD44 + si‐METTL3, or OE‐circCD44 + si‐HMBOX1 were subcutaneously transplanted into nude mice to observe the regulatory effect of circCD44 on ESCC growth. Here, METTL3 is linked to esophageal squamous cell carcinoma.