These genes were then refined using the Lasso machine learning algorithm, resulting in the identification of 10 risk genes for NSCLC: DCN, PTHLH, CRYAB, HMGCS1, DSG3, ZFP36L2, SCAND1, NUDT4, NDUFA4L2 and RPL36A (Figure 1C,D) (Table S5). This evidence concerns the gene NUDT4 and non-small cell lung carcinoma.