We analysed the mutation patterns of 10 NSCLC risk genes and found mutations in DCN, HMGCS1, ZFP36L2, DSG3 and SCAND1, where the mutation patterns of DSG3 and SCAND1 were missense mutations, the mutation patterns of DCN were missense, nonsense and shifted‐code, the mutation patterns of HMGCS1 were missense and shifted‐code, and the mutation patterns of ZFP36L2 were nonsense mutation and missense mutation (Figure 6A). The gene discussed is HMGCS1; the disease is non-small cell lung carcinoma.