Increased levels of NSUN2 and NSUN2‐mediated m5C have been observed in various types of cancer, including gastric cancer (GC),69, 70 esophageal squamous cell carcinoma (ESCC),71 HCC,72 hypopharyngeal squamous cell carcinoma,73 prostate cancer (PCa),74 cervical cancer,75 nasopharyngeal carcinoma76 and uveal melanoma.77 The gene discussed is NSUN2; the disease is hepatocellular carcinoma.