A subsequent colocalization analysis (PPH4 > 0.8) confirmed that, of the 12 proteins linked to cognitive progression, 10 (ALKBH3, GLO1, IDO1, SERPINA3, SORD, TPST1, GM2A, MICB, SH3BGRL3, and TGFBI) shared causal variants with PD cognitive progression loci (Table S6, Figure 3). The gene discussed is TPST1; the disease is Parkinson disease.