While there is no direct evidence, this duality suggests that SH3BGRL3 may regulate multiple pathways that differentially affect various aspects of disease progression, such as influencing PD by stabilizing synaptic architecture and acting as a redox sensor, thereby protecting against α‐synuclein‐induced synaptic deficits and adjusting dysregulated intracellular signaling cascades [51]. The gene discussed is SH3BGRL3; the disease is Parkinson disease.