Concerning the identified progression‐related targets, ALKBH3, GLO1, IDO1, SERPINA3, SORD, TPST1, GM2A, MICB, SH3BGRL3, and TGFBI, we found them to be significantly associated with cognitive decline in the plasma of PD patients. This evidence concerns the gene SH3BGRL3 and Parkinson disease.