A subsequent colocalization analysis (PPH4 > 0.8) confirmed that, of the 12 proteins linked to cognitive progression, 10 (ALKBH3, GLO1, IDO1, SERPINA3, SORD, TPST1, GM2A, MICB, SH3BGRL3, and TGFBI) shared causal variants with PD cognitive progression loci (Table S6, Figure 3). This evidence concerns the gene IDO1 and Parkinson disease.