The upregulation of hypoxia-inducible factor (HIF) expression triggered by hypoxia in the AML microenvironment is associated with resistance to doxorubicin, possibly because HIF-1α enhances the expression of the YAP gene in AML cells, which stabilizes the binding of HIF-1α to its target genes [75]. This evidence concerns the gene HIF1A and acute myeloid leukemia.