CXCL8 and leukemia: IL-8 not only enhances the drug resistance of AML cells (e.g., etoposide) and promotes the survival of leukemia cells [78], but also interacts with the CXCR1 and CXCR2 on Tregs, facilitating the migration of Tregs to the tumor site and thereby suppressing effector T cells in the immune microenvironment.