Activation of STING can induce a potent immune response against pathogen infections and cancer, while imbalances of this pathway may lead to a variety of human diseases, including infectious diseases, autoimmune diseases, tumors, organ fibrosis, and neurodegenerative diseases (Hopfner and Hornung, 2020; Dvorkin et al., 2024). The gene discussed is STING1; the disease is neurodegenerative disease.