Mounting evidence has indicated that the abnormal activation of the cGAS-STING pathway is closely associated with the development of autoimmune diseases (AID) (Liu and Pu, 2023), nonalcoholic fatty liver disease (NAFLD), chronic inflammation, Parkinson’s disease, and cardiovascular diseases (Oduro et al., 2022). Here, CGAS is linked to metabolic dysfunction-associated steatotic liver disease.