In the classical STING signaling pathway, pathogen DNA, Cyclic Dinucleotides (CDNs) substances, tumor dsDNA, or aberrant cytosolic mtDNA are recognized by cyclic GMP-AMP (cGAMP) synthase (cGAS) (Decout et al., 2021), which then catalyzes the formation of cGAMP from GTP and ATP. Here, CGAS is linked to neoplasm.