LGR5 and neoplasm: After Clevers’ team in the Netherlands published their findings in 2009, reporting that leucine-rich repeat-containing G protein-coupled receptor 5 (Lgr5) positive ASCs in the mouse intestine were capable of forming the crypt-villus structure in vivo, organoid models of normal organs and tumor tissues can be observed in studies of multiple fields, including the stomach, colon, pancreas, kidney, prostate, brain, and retina (Barker et al., 2010; Spence et al., 2011; Sato et al., 2011; Gao et al., 2014; Eiraku and Sasai, 2011; Lancaster et al., 2013; Low et al., 2019; Boj et al., 2015).