Regarding preoperative serum albumin, we observed no differences in preoperative serum albumin levels and the risk of AL (3.6 g/dL vs. 3.5 g/dL, p=0.822). It has been studied and described that low preoperative levels of serum albumin [14,35] (<3.5g/dL) appear to be associated with an increased AL risk in patients suffering from various colorectal diseases, especially CRC and IBD (OR 2.8, 95% CI, 1.3-5.1, p=0.03) [38]. This evidence concerns the gene ALB and axial length measurement.