To unravel additional signatures of malaria‐driven selection, we genotyped four HLA class II genes, DRB1, DQA1, DQB1 and DPB1, in (almost) the same set of African populations previously analyzed for HLA‐A and HLA‐B (Sanchez‐Mazas et al. 2017). This evidence concerns the gene HLA-B and malaria.