While HLA class I molecules protect against the development of malaria through cytotoxic CD8+ T lymphocytotoxicity at the liver stage of P. falciparum infection (Aidoo and Udhayakumar 2000) and/or through interaction with Natural Killer cells (Tukwasibwe et al. 2020), HLA class II molecules trigger the production of specific antibodies (humoral response) against P. falciparum proteins at all stages of the parasitic infection (Fiorillo et al. 2017; Medhasi and Chantratita 2022; Meyer et al. 2006). Here, CD8A is linked to malaria.