G6PD and hemoglobinopathy: With regard to immune responses against malaria, it is also understood that a wide range of non‐HLA variants of the genome, such as markers involved in hemoglobin disorders (e.g., HbS), red cell polymorphisms (e.g., GYP Dantu) or enzymopathies (e.g., G6pD) play a major role in our defense against this disease (Kariuki and Williams 2020; Kariuki et al. 2020).