Based on the generalist versus specialist view of MHC‐mediated protection to infectious pathogens (Kaufman 2018, 2020), DPB1*01:01 may be more fastidious (i.e., binding a narrow range of peptides conferring strong protection) and DRB1*08:06 and DRB1*11:02 more promiscuous (i.e., binding a wider range of peptides conferring weaker protection) in malaria resistance. The gene discussed is HLA-DPB1; the disease is malaria.