From a transcriptional regulation perspective, Brain-Specific Homeobox/POU Domain Protein 2 (BRN2) and Achaete-Scute Family BHLH Transcription Factor 1 (ASCL1) have been identified as master regulator of neuroendocrine differentiation process in PCa (27, 28). Here, ASCL1 is linked to posterior cortical atrophy.