(26) found that capsaicin activation of TRPV1 down-regulates the expression of key EMT transcription factors Snail1 and Twist1, and also down-regulates the expression of MMPs-2 and MMPs-9, and ultimately significantly inhibits the migration, invasion and adhesion of bCPAP cells in thyroid papillary carcinoma. The gene discussed is TRPV1; the disease is thyroid gland papillary carcinoma.