N-glycans were proven to provide multifaceted protection to pancreatic adenocarcinoma cells by lytic immune synapse formation and interfering with transcriptional activation, cytotoxicity, and cytokine production through inhibiting N-glycan synthesis by knocking out mannoside acetyl-glucosaminyltransferase 5 (MGAT5) (55). This evidence concerns the gene MGAT5 and pancreatic adenocarcinoma.