Moreover, ABSI seems to describe changes in circulating insulin and lipoproteins more accurately, compared with BMI (11), and ABSI can help determine the risk of sarcopenia in overweight/obese individuals (26).Previous studies have shown (6) that BMI, as a single quantitative indicator of obesity, cannot distinguish between fat and muscle content and cannot reflect individual fat distribution, while ABSI was selected as an indicator in our study to make up for this deficiency. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.