PLOD1 and precocious puberty: The girl was diagnosed with central precocious puberty according to the following diagnostic criteria: early onset of sexual characteristics, with breast development occurring before the age of 7.5 years; pelvic ultrasound showed that the girl’s uterus and ovaries were enlarged, and multiple follicles ≥4 mm in diameter were seen in the ovaries; serum gonadotropins and sex hormones reach pubertal levels, peak LH ≥5.0 IU/L and LH peak/FSH peak> 0.6, suggesting initiation of the gonadal axis; bone age ≥1 year above actual age; accelerated linear growth (1).