Though Th2 cells are the dominant cells in the acute phase of AD, dDC and LCs also contribute to the differentiation of Th22 and Th17 cells through excretion of IL-6/tumor necrosis factor α (TNFα) and IL-6/IL-21/Transforming growth factor β (TGFβ), respectively [21,22]. The gene discussed is IL6; the disease is Alzheimer disease.