Several studies have demonstrated that disruption of the CISH gene, the gene encoding the CIS protein, enhances the persistence and survival of CAR-NK cells in the immunosuppressive TME and leads to superior control of tumors compared to CIS + CAR-NK cells (Daher et al., 2021b; Guo et al., 2022; Guo C. et al., 2021). This evidence concerns the gene CISH and in situ carcinoma.