To this end, the effects of conditional inactivation of the glucocorticoid receptor (GR) on astrocytes were investigated in GRCx30CreERT mice, using a model of PD induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) injection (Maatouk et al., 2019). This evidence concerns the gene NR3C1 and Parkinson disease.