One proposed mechanism by which Cx43 exacerbates and sustains the neuroinflammation in MS is linked to the aberrant release of ATP, which serves as activation signal of the NOD-like receptor protein 3 (NLRP3) inflammasome (Malhotra et al., 2020; Kwakowsky et al., 2023). The gene discussed is GJA1; the disease is myeloid sarcoma.