HPS strains of different serotypes or unclassifiable HPS could be combined to produce polyclonal antibodies in mice after immunization, and the serum levels of IgM + IgG and IgG1 + IgG2 in mice were significantly increased after the second and third immunization, and high levels of B cell populations, cytotoxicity, and T helper lymphocytes were observed, indicating that a cell-mediated immune response was activated. Here, CD40LG is linked to Hermansky-Pudlak syndrome.